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Title:Centrosome polarization delivers secretory granules to the immunological synapse.
Authors:J.C.Stinchcombe, E.Majorovits, G.Bossi, S.D.Fuller, G.M.Griffiths
Sample:Immunological synapse between a cytotoxic T lymphocyte and a target cell
Aggregation state:Individual structure (50 angstroms resolution)
Red flagLatest update:2011-05-26
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Visualization
Tomogram of the immunological synapse between a cytotoxic T lymphocyte (CTL) and a target cell. The microtubule organization centre (MTOC) is polarized to the cell-cell contact site. The electron-dense lytic granules are transported along the microtubules to the synaptic cleft. Here they probably fuse with the membrane and excrete the cytotoxic proteins that trigger the death of the target cell. (See the masks representing models of the synaptic cleft, microtubules, centriole, lytic granules and Golgi apparatus.)
Suggested contour level:
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Atlas images are either supplied by the depositor or generated by EMDataBank using UCSF Chimera.
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