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Title:Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Authors:Wong W, Bai X-C
Sample:Plasmodium falciparum 80S ribosome bound to mefloquine
Method:Single particle reconstruction (3.2 angstroms resolution)
Red flagLatest update:2017-08-30
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Summary
Status: Released
Deposition date: 2017-01-27
Deposition site: PDBe
Processing site: PDBe
Header release date: 2017-03-01
Map release date: 2017-03-01
Primary citation: Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J
Nat Microbiol (2017) 2, pp. 17031-17031 [PubMed 28288098] [DOI]
Sample: Plasmodium falciparum 80S ribosome bound to mefloquine
Resolution: 3.2 Å (determined by FSC 0.143 CUT-OFF)
Fitted PDB:
PDB Authors PubMed Status
5umdWong, W., Bai, X.-C., Brown, A., Scheres, S., Baum, J.28288098Released