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Title:Cryo-EM Structures of ASC and NLRC4 CARD Filaments Reveal a Unified Mechanism of Nucleation and Activation of Caspase-1
Authors:Li Y, Fu T, Wu H
Sample:Caspase recruitment domain of Apoptosis-associated speck-like protein containing a CARD
Method:Helical reconstruction (3.17 angstroms resolution)
Red flagLatest update:2018-12-05
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Summary
Status: Released
Deposition date: 2018-06-12
Deposition site: RCSB
Processing site: RCSB
Header release date: 2018-06-27
Map release date: 2018-10-10
Primary citation: Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H
Proc. Natl. Acad. Sci. U.S.A. (2018) 115, pp. 10845-10852 [PubMed 30279182] [DOI]
Sample: Caspase recruitment domain of Apoptosis-associated speck-like protein containing a CARD
Resolution: 3.17 Å (determined by FSC 0.143 CUT-OFF)
Fitted PDB:
PDB Authors PubMed Status
6n1hLi, Y., Fu, T., Wu, H.30279182Released